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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Genetic Protein Tyrosine Phosphatase Ankylosing spondylitis HLA-DRB1 Chains Biologie computationnelle des systèmes C-Type Aged Tunisia Receptors Complex genetic disease Anti-Idiotypic Age Factors Humans Young Adult HLA-DR Antigens Animals Rheumatoid Factor CASP7 GENE Antirheumatic Agents Algeria Anti-citrullinated protein antibodies CARD Signaling Adaptor Proteins Family Logical modelling Network inference Autoimmunity Biocuration Rheumatoid Phenotype Boolean simulations Linkage Disequilibrium APOPTOSIS Biomarkers Environment Risk Factors Polymorphism Shared Epitope Male Alleles Reproducibility Adult Single Nucleotide Family Health Autoantibody Production 80 and over European Continental Ancestry Group Europe Antigen Presentation Female Autoantibodies Systems biology Boolean models Génétique POLYMORPHISM Rheumatoid Arthritis Arthritis Rheumatoid Arthritis Patient Polyarthrite rhumatoïde In silico simulations Ankylosing Biologie des systèmes Antibodies Case-Control Studies RHEUMATOID ARTHRITIS Autoimmune thyroid diseases ASSOCIATION STUDY Genetics Disease maps Algerian population Computational systems biology Epitopes African Continental Ancestry Group Odds Ratio Analysis Genetic Predisposition to Disease Autoimmune thyroid disease Annotation standards Databases Binding Sites Genetic Association Studies Genotype Gene Frequency PTPN22 gene ATP Binding Cassette Transporter Boolean networks Genetic Linkage Rheumatoid arthritis Autoimmune Diseases Biological pathway France Middle Aged Age of Onset HLA-DRB1 Non-Receptor Type 22 Antigens Haplotypes Cohort Studies Association study Adolescent ABCB1

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