Cancer Among Adolescents and Young Adults Between 2000 and 2016 in France: Incidence and Improved Survival

Thomas Raze (1, 2) , Brigitte Lacour (3, 2, 4) , Anne Cowppli-Bony (5, 6, 7) , Patricia Delafosse (8, 9) , Michel Velten (10) , Brigitte Trétarre (11) , Gautier Defossez (12) , Karima Hammas (13) , Anne-Sophie Woronoff (8, 14) , Olivier Ganry (15, 16) , Sandrine Plouvier (8, 17) , Gaelle Coureau (18) , Anne-Valérie Guizard (19, 20) , Simona Bara (21) , Alain Monnereau (18) , Laetitia Daubisse-Marliac (22, 23, 24) , Xavier Troussard (25) , Tania d'Almeida (26) , Isabelle Baldi (18, 27) , Véronique Bouvier (20) , Nicolas Boissel (28) , Jacqueline Clavel (3, 29, 4) , Emmanuel Desandes (3, 2, 4)

1 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
2 RNTSE - Registre National des Tumeurs Solides de l'Enfant
3 CRESS - U1153 - Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent
4 RNCE - Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy]
5 Francim - French network of cancer registries [Toulouse]
6 Registre des cancers de Loire‐Atlantique et Vendée
7 ILIAD - Imaging and Longitudinal Investigations to Ameliorate Decision-making [Nantes]
8 FRANCIM
9 Registre des cancers de l’Isère [CHU de Grenoble]
10 CRLCC Paul Strauss
11 Registre des Tumeurs de l'Hérault
12 CIC - Poitiers
13 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
14 Registre des tumeurs du Doubs et du Territoire de Belfort [CHRU Besançon]
15 CHU Amiens-Picardie
16 CHIMERE - CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516
17 GCS-C2RC - Registre général des cancers de Lille et de sa région
18 BPH - Bordeaux population health
19 Registre Général des Tumeurs du Calvados
20 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers
21 Registre des cancers de la Manche [CHPC - Site Louis Pasteur]
22 A&O - A&O (Apprentissage et Optimisation)
23 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
24 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
25 CHU Caen
26 Université Sorbonne Paris Nord
27 EPICENE - Cancer environnement
28 AP-HP - Hopital Saint-Louis [AP-HP]
29 RNHE - Registre National des Hémopathies malignes de l'Enfant

Purpose: This study was undertaken to determine cancer survival and describe the spectrum of cancers diagnosed among French adolescent and young adult (AYA) population. Methods: All cases of cancer diagnosed in 15-24 years, recorded by all French population-based registries (18% of the French population), over the 2000-2016 period, were included. Age-standardized incidences rates (ASR), conventional annual percentage change (cAPC) of incidence over time, and 5-year overall survival (5yOS) were calculated. Results: We analyzed 2,734 cancer diagnoses in adolescents and 4,199 in young adults. Overall incidence rates were 231.9/106 in 15-19 year olds and 354.0/106 in 20-24 year olds. The most frequently diagnosed cancers in male AYA were malignant gonadal germ-cell tumors (GCT), Hodgkin lymphoma (HL), and malignant melanoma, and were HL, thyroid carcinoma, and malignant melanoma in females. Cancer incidence was stable over time with a cAPC of 0.8% (p=0.72). For all cancers combined, 5yOS was 86.6% (95%CI: 85.8-87.4), greater than 85% for HL, non-Hodgkin lymphomas (NHL), GCT, thyroid carcinomas, and malignant melanomas, and around 60% and lower for osteosarcomas, Ewing tumors, hepatic carcinomas, and rhabdomyosarcomas. The 5yOS has significantly improved from 2000-2007 to 2008-2015 for all cancers pooled, with a substantial gain of 4% for 15-19 year-olds, and 3% for 20-24 year-olds. Conclusion: Notwithstanding the encouraging results for some cancers, and overall, persistent poorer survivals in AYA were shown compared to children for acute lymphoblastic leukemia, osteosarcoma, Ewing tumor, rhabdomyosarcoma and malignant hepatic tumors. These disparities require further investigation to identify and address the causes of these inferior outcomes.

Keywords: Adolescents; Young Adults; Cancer; Incidence; Survival; Trends

Domains: Life Sciences [q-bio]

Thomas Raze, Brigitte Lacour, Anne Cowppli-Bony, Patricia Delafosse, Michel Velten, et al.. Cancer Among Adolescents and Young Adults Between 2000 and 2016 in France: Incidence and Improved Survival. Journal of Adolescent and Young Adult Oncology, 2021, 10 (1), pp.29-45. ⟨10.1089/jayao.2020.0017⟩. ⟨hal-04020187⟩