Final Products of One-Electron Oxidation of Cyclic Dipeptides Containing Methionine Investigated by IRMPD Spectroscopy: Does the Free Radical Choose the Final Compound?

Yining Jiang (1) , Suvasthika Indrajith (2, 3) , Ariel Francis Perez Mellor (4) , Thomas Bürgi (4) , Marc Lecouvey (5) , Carine Clavaguéra (1) , Enrico Bodo (6) , Chantal Houée-Levin (1) , E. Loire (1) , Giel Berden (7) , Jos Oomens (7, 8) , Debora Scuderi (1)

1 ICP - Institut de Chimie Physique
2 CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique
3 Stockholm University
4 UNIGE - Université de Genève = University of Geneva
5 CSPBAT - Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques
6 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
7 Radboud University [Nijmegen]
8 van ‘t Hoff Institute for Molecular Sciences

Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) and the hydroxyl radical (• OH) have specific functions in biological processes, while their uncontrolled production and reactivity are known to be determining factors in pathophysiology. Methionine (Met) residues act as endogenous antioxidants, when they are oxidized into methionine sulfoxide (MetSO), thus depleting ROS and protecting the protein.

Mots clés: One-electron oxidation -radiolysis IRMPD spectroscopy tandem mass spectrometry cyclic peptides; One-electron oxidation; -radiolysis; IRMPD spectroscopy; tandem mass spectrometry; cyclic peptides

Domaines: Chimie théorique et/ou physique; Chimie-Physique [physics.chem-ph]

Yining Jiang, Suvasthika Indrajith, Ariel Francis Perez Mellor, Thomas Bürgi, Marc Lecouvey, et al.. Final Products of One-Electron Oxidation of Cyclic Dipeptides Containing Methionine Investigated by IRMPD Spectroscopy: Does the Free Radical Choose the Final Compound?. Journal of Physical Chemistry B, 2022, 126 (48), pp.10055-10068. ⟨10.1021/acs.jpcb.2c06541⟩. ⟨hal-04089741⟩