Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults

Valentin Ourry (1, 2, 3, 4, 5) , Julie Gonneaud (1, 5, 2) , Brigitte Landeau (1, 5, 2) , Inès Moulinet (1, 5, 2) , Edelweiss Touron (1, 5, 2) , Sophie Dautricourt (1, 5, 2) , Gwendoline Le Du (1, 5, 2) , Florence Mézenge (1, 5, 2) , Claire André (1, 5, 2, 4, 3) , Alexandre Bejanin (1, 5, 2) , Siya Sherif (1, 5, 2) , Natalie L Marchant (6) , Léo Paly (1, 5, 2) , Géraldine Poisnel (1, 5, 2) , Denis Vivien (1, 5, 2, 3) , Anne Chocat (1, 5, 2) , Anne Quillard (1, 5, 2) , Eglantine Ferrand Devouge (1, 5, 2, 7, 8) , Vincent de la Sayette (4, 3, 2) , Géraldine Rauchs (4, 3, 2) , Eider M Arenaza-Urquijo (1, 5, 2, 9) , Gaël Chételat (1, 5, 2)

1 PhIND - Physiopathologie et imagerie des troubles neurologiques
2 Cyceron - GIP Cyceron
3 CHU Caen
4 NIMH - Neuropsychologie et imagerie de la mémoire humaine
5 BB@C - Institut Blood and Brain @ Caen-Normandie [Caen]
6 UCL - University College of London [London]
7 CHU Rouen
8 CIC Rouen - Centre d'Investigation Clinique [CHU Rouen]
9 Pasqual Maragall Foundation

analyses revealed that the relationships with physical health QoL concerned the anterior insula and ventrolateral prefrontal cortex, and the corpus callosum, corona radiata, inferior frontal white matter and cingulum. Selfperceived daily living activities and self-perceived pain and discomfort were the items that contributed the most to these associations with gray matter volume and white matter mean kurtosis, respectively. Conclusions: Better self-perceived physical health, encompassing daily living activities and pain and discomfort, was the only QoL domain related to brain structural integrity including higher global gray matter volume and global white matter microstructural integrity in cognitively unimpaired older adults. The relationships involved brain structures belonging to the salience network, the pain pathway and the empathy network. While previous studies showed a link between objective measures of physical health, our findings specifically highlight the relevance of monitoring and promoting self-perceived physical health in the older population. Longitudinal studies are needed to assess the direction and causality of the relationships between QoL and brain integrity.

Mots clés: Amyloid imaging; Multimodal neuroimaging; Neurodegeneration; Older adults; Quality of life; White matter microstructure

Domaines: Sciences cognitives

Valentin Ourry, Julie Gonneaud, Brigitte Landeau, Inès Moulinet, Edelweiss Touron, et al.. Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults. NeuroImage, 2021, 231, pp.117819. ⟨10.1016/j.neuroimage.2021.117819⟩. ⟨inserm-04386174⟩